WebResearch Interests: Natural Product Chemistry, Extracellular-targeted Drug-Conjugates (EDCs), Conjugation Chemistry, Drug Delivery, Linker Technologies for EDCs, Azidation … Web27 Oct 2010 · 3,4-Diamino-2,5-dicarboxamidothieno(2,3-b)thiophene 1 was allowed to react with CS 2 , carbonyl compounds, ethyl chloroformate, S,S-acetals, and oxallyl chloride to give thienopyrimidines 2-6 and thieno-1,4-diazepine 7 .

Anticancer activity of some novel thieno [2, 3-d] pyrimidine …

WebRecent Report on Thieno[2,3-d]pyrimidines. Their Preparation Including Microwave and Their Utilities in Fused Heterocycles Synthesis Web4 Apr 2015 · Of particular interest, these thienopyrimidines showed good PI3Kα/mTOR selectivity, and the selectivity was, in general, determined to be around 100-fold. This is a … tabel kms

Dr. Narahari Deshapande - Lecturer - VPH College, Dharwad

WebThienopyrimidines (TP), comprising a thiophene ring fused with pyrimidine, are famous bioisosteres to purines, an essential part of the human metabolome. This scaffold has … Web21 Jul 2024 · This motivated the synthesis of new thienopyrimidines possessing benzimidazole fragments in order to evaluate their cytotoxicity to the above-mentioned cell lines. Objective: The objectives of the study were to design and synthesize a novel series of thieno[2,3-d]pyrimidines bearing biologically active moieties, such as 1,3-disubstituted ... Web26 Dec 2006 · Publisher Summary The chapter analyzes the results of studies on the synthesis, chemical transformations, and biological activities of thienopyrimidines. The known approaches to the synthesis of thienopyrimidines can be divided into two main groups: construction of the pyrimidine ring by intramolecular cyclization of thiophene … brazilian tanager