WebApr 5, 2024 · The underlying mechanisms that determine gene expression and chromatin accessibility in retinogenesis are poorly understood. Herein, single-cell RNA sequencing and single-cell assay for transposase-accessible chromatin sequencing are performed on human embryonic eye samples obtained 9–26 weeks after conception to explore the … BLIMP-1 is an important regulator of plasma cell differentiation. During B cell development, a B cell can either differentiate into a short-lived plasma cell or into a germinal center B cell after receiving proper activation and co-stimulation. BLIMP-1 acts as a master gene regulating the transcriptional network that regulates B cell terminal differentiation. Except for naïve and memory B cells, all antibody secreting cells express BLIMP-1 regardless of their location and differentiatio…
B-cell differentiation is pressuromodulated as determined by ...
WebMay 15, 2006 · PRDM1 acts as a master regulator in the differentiation of mature B … WebPRDM1/BLIMP-1, a master regulator of plasma-cell differentiation, is frequently … destiny ford photography
A p38α-BLIMP1 signalling pathway is essential for plasma cell ...
WebSep 26, 2024 · Antibody-secreting plasma cells are effectors of the humoral immune … WebGenetic studies in lymphoma have identified a role for a number of key genes that are … WebPRDM1/BLIMP-1 is a master transcription factor regulating downstream cytokines. It is activated by TLRs and IRF-4, and is crucial in T cell, B cell, and myeloid lineage cell differentiations. As a potent repressor of beta-interferon (IFN-β), BLIMP-1 competes for interferon regulatory factors (IRF) binding sites in the IFN-β promoter due to ... destiny focusing strike