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Phosphogluconolactonase

WebOct 2, 2024 · γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A Highlights • G6PD knockdown activates PP2A to neutralize activated LKB1-AMPK signaling • G6PD product 6-phosphogluconolactone (6PGL) promotes PP2A inhibition by Src • WebMar 21, 2024 · The hexose monophosphate shunt is a crucial pathway in a variety of microorganisms owing to its vital metabolic products and intermediates such as NADPH, …

Dual-Targeting of Arabidopsis 6-Phosphogluconolactonase 3 …

WebMar 21, 2024 · The enzyme 6-phosphogluconolactonase catalyses the second step of this pathway, converting 6-phosphogluconolactone to 6-phosphogluconic acid. This enzyme has been known to have a significant involvement in growth, pathogenesis and sensitivity to oxidative stress in bacterial and protozoal pathogens. WebAug 1, 2011 · Fusions of the first two enzymes in the pentose phosphate pathway, glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconolactonase (6PGL), have been previously described in two distant clades, chordates and species of the malarial parasite Plasmodium. We have analyzed genome and expressed sequence data from a variety of … lambeau\\u0027s shadow vacation home green bay wi https://pixelmotionuk.com

Characterization of Arabidopsis 6-Phosphogluconolactonase T …

WebApr 14, 2024 · Pseudomonas cannabina pv. alisalensis (Pcal) causes bacterial blight on cabbage. We previously conducted a screening for reduced virulence using Tn5 transposon mutants and identified one of the transcriptional factors, HexR, as a potential Pcal virulence factor. However, the role of HexR in plant pathogenic Pseudomonas virulence has not … WebMay 20, 2009 · The PPP contains a series of reactions catalyzed by seven different enzymes: glucose-6-phosphate 1-dehydrogenase (G6PDH), 6-phosphogluconolactonase … WebThe sequence from glucose to pyruvate is often called the Embden–Meyerhof pathway, named after two German biochemists who in the late 1920s and ’30s postulated and … heloc boa status

Leishmania donovani 6-phosphogluconolactonase: Crucial for

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Phosphogluconolactonase

O95336 - UniProt

6-Phosphogluconolactonase (EC 3.1.1.31, 6PGL, PGLS, systematic name 6-phospho-D-glucono-1,5-lactone lactonohydrolase) is a cytosolic enzyme found in all organisms that catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconic acid in the oxidative phase of the pentose … See more 6PGL hydrolysis of 6-phosphogluconolactone to 6-phosphogluconic acid has been proposed to proceed via proton transfer to the O5 ring oxygen atom, similar to xylose isomerase See more 6PGL in Homo sapiens exists as a monomer at cytosolic physiological conditions, and is composed of 258 amino acid residues with a total molecular mass of ~30 kDa. The tertiary structure of the enzyme utilizes an α/β hydrolase fold, with both parallel and … See more • 6-phosphogluconolactonase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Collard F, Collet JF, Gerin I, Veiga-da-Cunha M, Van Schaftingen E … See more 6-phosphogluconolactonase catalyzes the conversion of 6-phosphogluconolactone to 6-phosphogluconic acid, both intermediates in the oxidative phase of the pentose phosphate pathway See more Malarial parasites Plasmodium berghei and Plasmodium falciparum have been shown to express a bi-functional enzyme that exhibits both See more Webgenase; pgl, 6-phosphogluconolactonase; and gncl, gluconate 6- phosphate dehydrogenase. The lactonase mutants were found as a third class of glucose- negative derivatives of a pgi mutant, which could grow slowly on glucose, but markedly slower than the parental pgi mutant. Genetic mapping showed that pgl was a separate gene from zwj ...

Phosphogluconolactonase

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WebMay 20, 2009 · The PPP contains a series of reactions catalyzed by seven different enzymes: glucose-6-phosphate 1-dehydrogenase (G6PDH), 6-phosphogluconolactonase (6PGL), 6-phosphogluconate dehydrogenase (6PGDH), ribose-5-phophate isomerase (RPI), ribulose-5-phosphate 3-epimerase (RPE), transketolase (TK) and transaldolase (TA) … Web6-phosphogluconolactonase: ( fos'fō-glū'kŏ-nō-lak'tō-nās ), A hydrolase that catalyzes the hydrolysis of 6-phospho- d -glucono-δ-lactone to produce 6-phospho- d -gluconate; this enzyme is a part of the pentose phosphate shunt.

WebENZYME - 3.1.1.31 6-phosphogluconolactonase ENZYME entry: EC 3.1.1.31 Accepted Name 6-phosphogluconolactonase Reaction catalysed 6-phospho-D-glucono-1,5-lactone + H2O … WebAug 2, 2006 · In this context, the crystal structure of 6-phosphogluconolactonase (6PGL) from T. brucei, the second enzyme from PPP, was determined at 2.1 Angstroms resolution. Comparison of its sequence and structure to other related proteins in the 6PGL family with a known structure (Thermotoga maritima Tm6GPL 1PBT and Vibrio cholerae Vc6PGL …

WebThe enzyme 6-phosphogluconolactonase catalyses the second step of this pathway, converting 6-phosphogluconolactone to 6-phosphogluconic acid. This enzyme has been known to have a significant involvement in growth, pathogenesis and sensitivity to oxidative stress in bacterial and protozoal pathogens.

Web6-Phosphogluconolactonase (6PGL, PGLS) is a cytosolic enzyme found in all organisms that catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconic acid in the …

Web6-phosphogluconolactonase EC number EC:3.1.1.31 ( UniProtKB ENZYME Rhea) Short names 6-P-gluconolactonase; Pgl Gene names Name pgl Synonyms ybhE Ordered locus … heloc bmo harrisWeb6-Phosphogluconolactonase was purified to apparent homogeneity in a four-step procedure from bovine erythrocytes. The extent of purification and the kinetic properties of the … heloc best ratesWebSynonym (s): Anti-6PGL)] antibody produced in rabbit, Anti-GDH/6PGL endoplasmic bifunctional protein precursor [Includes: Glucose 1-dehydrogenase antibody produced in … lambeau\\u0027s flower mound