WebOnvansertib (Synonyms: NMS-1286937; NMS-P937) 目录号: HY-15828 纯度: 99.16% COA 产品使用指南 nMS-1286937 是一种有效、高选择性、可口服的 PLK1 抑制剂, IC50 值为 2 nM。 MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务 我们将采用定制合成服务的方式为您快速提供所需产品和技术服务 Onvansertib … WebASSAY IMPURITIES Procedure Organic Impurities (added) PERFORMANCE TESTS ADDITIONAL REQUIREMENTS Dissolution Packaging and Storage and USP Reference …
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Web14 de abr. de 2014 · EnVision for fluorescence polarization, a. fluorescein dilution series (Cat# C557-100. from PerkinElmer Life Sciences) was studied. Samples were pipetted into a 384-well plate. using volumes of 50 µL/well. Standard. deviation for the whole plate using 1 nM. fluorophore was plotted against. measurement time/plate. Web12 de abr. de 2024 · About the Phase 1b/2 Trial of Onvansertib in KRAS-mutated mCRC. This is a multi-center, open-label Phase 1b/2 trial of onvansertib in combination with standard-of-care FOLFIRI and Avastin ® (bevacizumab) to evaluate the safety and preliminary efficacy of the combination regimen in the second-line treatment of patients … tsi3 affinity tag
PLK Inhibition PLK Activation PLK Inhibitor Review
WebThe inhibitory activity of putative kinase inhibitors and the potency of selected compounds are determined using a trans-phosphorylation assay. Specific peptide or protein … WebFluorescence polarization immunoassay ( FPIA) is a class of in vitro biochemical test used for rapid detection of antibody or antigen in sample. FPIA is a competitive homogenous assay, that consists of a simple prepare and read method, without the requirement of separation or washing steps. WebBI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. ... Onvansertib (NMS-P937, PCM-075, NMS1286937) is an orally available, ... tsi3 fairway wood review