Web3 de ago. de 2024 · HIF-1 regulates lipid metabolism in a specific way in the liver by sensing the cellular microenvironment under different conditions. ... For instance, HIF-1α-deficient mice show reduced production of thrombin and plasminogen activator inhibitor-1, indicating that HIF-1α signaling contributes to hemostasis in APAP liver toxicity. Web1 de mar. de 2012 · Highlights Inhibitor of HIF-1 pathway is an important class of therapeutic agents with far-reaching implications in oncology and related area. We review recent advances on small molecule inhibitors of HIF-1 function. We give an overview of these agents in terms of their biological modes on this pathway. We outlook HIF-1 …
Evaluation of Naturally Occurring HIF-1 Inhibitors for Pulmonary ...
Web低氧诱导因子 -1(hypoxia-inducible factor-1,HIF-1)是细胞对低氧反应的重要转录因子,低氧时细胞可经HIF-1信号通路诱导一系列适应性反应,如血管内皮生长因子(vascular endothelial growth factor,VEGF)的表达增高、无氧代谢等,以利于增加局部氧供给和降低氧消耗,从而达到维持内环境平衡的目的[5]。 Web20 de out. de 2009 · Identifying an inhibitor of HIF-1 dimerization would be particularly desirable as a defined and selective mechanism of action, although conventional wisdom holds that the large interfaces involved in protein dimerization are difficult to … inboxmail srl
Action Sites and Clinical Application of HIF-1α Inhibitors
Web2 de mai. de 2024 · Figure 1. Identification of HIF inhibitors. (A) Hep3B-c1 cells were stably transfected with firefly luciferase (FLuc) reporter p2.1, which contains a hypoxia-response element (HRE), and Renilla luciferase (RLuc) reporter pSVR. Web21 de jun. de 2024 · This study provides the pre-clinical proof of concept for a novel triple combination strategy including blocking HIF-1α transcription activity along vaccination and PD-1 blocking immunotherapy. Not to be confused with Factor Inhibiting HIF Asparaginyl Hydroxylase Inhibitors Hypoxia-inducible factor prolyl hydroxylase Inhibitors (HIF-PHIs) also known as hypoxia-inducible factor stabilizers (HIF stabilizers) are a novel class of drugs that act by inhibiting hypoxia-inducible factor-proline dioxygenase (HIF prolyl-hydroxylase) which is responsible for breaking down the hypoxia-inducible factor (HIF) … inboxops