WebMar 1, 1999 · Abstract. Bombesin-like peptides such as gastrin-releasing peptide (GRP) have been shown to play a role in cancer as autocrine growth factors that stimulate tumor growth through specific receptors. To search for potential clinical indications for GRP analogues, it is important to identify human tumor types expressing sufficient amounts of … WebGastrin-releasing peptide (GRP), the 27 amino acid mammalian homolog of the 14 amino acid amphibian peptide bombesin (reviewed in Ref. 1), is present in a variety of different mammalian tissues, in particular the brain, the gastrointestinal (GI) tract, and the lung. GRP functions as both a neuroculatory hormone and a tissue-specific growth factor.
Gastrin-Releasing Peptide Receptor - an overview
WebOct 1, 2016 · Receptor targeted nuclear imaging directed against molecular markers overexpressed on breast cancer (BC) cells offers a sensitive and specific method for BC imaging. Currently, a few targets such as estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), somatostatin receptor … WebMay 16, 2024 · Expression of gastrin-releasing polypeptide (GRP; 137260) and its receptor in tumors suggests that these molecules are part of an autocrine loop for growth. Spindel et al. (1990) cloned the human GRP receptor cDNA from a library made from a small cell lung carcinoma cell line using the mouse GRP receptor. how do processors affect gaming
Gastrin-Releasing Peptide Receptor Targeting in Cancer
WebGastrin-releasing-peptide-receptor (GRPR, or BB2) is upregulated in several tumor types, including prostate ( Fig. 7 ), breast, small-cell lung and urothelial cancers. A variety of GRPR antagonist radiotracers have been radiolabeled ( Mansi et … WebGastrin-releasing peptide (GRP), the 27 amino acid mammalian homolog of the 14 amino acid amphibian peptide bombesin (reviewed in Ref. 1), is present in a variety of different … WebUsing antisera raised against the N-terminal (1-16) or the C-terminal part of the bombesin (BBN)-like peptide gastrin-releasing peptide (GRP) and against the C-terminus of pro-GRP, GRP- and pro-GRP-like immunoreactivity (IR) was detected by immunostaining in freshly dispersed rat anterior pituitary (AP) cells and in reaggregate AP cells cultured in … how do proctored online exams work