WebFerrDb is an open-source, open access, manually curated and continuously updated database. FerrDb is made available thanks to researchers who keep bringing us … WebFerrDb is a database for regulators of ferroptosis. It is the first database in this domain in the world.

Identification of ferroptosis-associated genes exhibiting altered ...

WebSep 17, 2024 · Then, we extracted 61 mmu-FRGs from 390 entries of the FerrDb database and literature reporting and 294 mmu-IRGs from 2013 entries of the ImmPort database (Figure 1, Figure 2D–E, Figures S2 and 3, Tables S2 and 3). WebNov 25, 2014 · Receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis is thought to be the pathophysiologically predominant pathway that leads to regulated necrosis of parenchymal cells in ischemia-reperfusion injury (IRI), and loss of either Fas-associated protein with death domain (FADD) or caspase-8 is known to sensitize tissues to undergo … cybernetically definition

Synchronized renal tubular cell death involves ferroptosis

WebSep 23, 2024 · We first obtained 259 known ferroptosis genes from FerrDb [10], including 108 ferroptosis driver genes, 69 ferroptosis suppressor genes, and 111 ferroptosis … WebJul 16, 2015 · We further found that the cell surface transferrin receptor and the glutamine-fueled intracellular metabolic pathway, glutaminolysis, played crucial roles in the death process. Inhibition of glutaminolysis, the essential component of ferroptosis, can reduce heart injury triggered by ischemia/reperfusion, suggesting a potential therapeutic ... WebNov 8, 2024 · We then developed FerrDb, the first manually curated database for regulators and markers of ferroptosis and ferroptosis-disease associations. The database has a … cybernetic agent