Cisplatin pathway
WebApr 15, 2024 · A 64-year-old man exhibited lack of efficacy during treatment with pirarubicin, gemcitabine and cisplatin for metastatic, high-grade non-muscle invasive bladder … WebMar 20, 2024 · Cisplatin (CDDP) is a platinum-based antitumor drug [ 1 ]. Its widespread use in the treatment of breast cancer, ovarian cancer, and other cancers has greatly improved the survival rate of patients [ 1 – 4 ]. However, this process is often accompanied by serious side effects, including nephrotoxicity and ototoxicity [ 5 ].
Cisplatin pathway
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WebApr 28, 2006 · The FA/BRCA pathway regulates the cellular response to cisplatin and other DNA cross-linking agents ( 16 ). The pathway is governed by the coordinate activity of several FA proteins. In response to cross-linkers, a protein complex composed of at least eight FA proteins (A, B, C, E, F, G, L, M) monoubiquitinates the FANCD2 protein ( 17 – 19 ). WebMar 22, 2024 · We found that PRDX1 enhanced autophagy by activating the PTEN (phosphatase and tensin homolog)-AKT/protein kinase B signaling pathway in SGNs that were incubated with cisplatin, and the activation of autophagy protected SGNs against cisplatin-induced damage by reducing oxidative stress and apoptosis in SGNs. Results
WebCisplatin also plays an interesting role in the history of chemistry. First synthesized in the 1800s, long before anyone thought of using it against cancer, cisplatin was a target … WebDec 8, 2024 · Cisplatin, activated by intracellular hydrolysis of chlorides, binds to DNA to form monoadducts as well as intra- and interstrand DNA cross-links [ 3 ]. As a result, it …
WebMar 22, 2024 · This study aims to identify pathway involvement in the development of cisplatin (cis-diamminedichloroplatinum (II); CDDP) resistance in A549 lung cancer (LC) cells by utilizing advanced...
WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared.
WebCisplatin-induced DNA lesions and repair mechanisms. A) The nucleotide excision repair (NER) pathway is responsible for removing cisplatin-induced DNA adducts (such as 1,2 … dhfl loan against propertyWebCisplatin (CP), cis-diamminedichloroplatinum(II), is a potent anti-tumor agent extensively used in cancer therapy, but its frequent application leads to the development of … cigar shop bourbon streetWebNov 20, 2014 · The findings show that when activated, the STING pathway triggers a natural immune response against the tumor. This includes production of chemical signals that help the immune system identify tumor cells and generate specific killer T cells. cigar shop beavertonWebCisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked DNA adducts … cigar shop brusselsWebMar 1, 2024 · Cisplatin represents a potent chemotherapeutic molecule with wide use in a broad spectrum of malignant diseases1. Unfortunately, ototoxicity, neurotoxicity, and nephrotoxicity are serious undesirable effects of cisplatin that quite limit its application2. dhfl loan account loginWebApr 4, 2010 · Cisplatin (cis-diamminedichloroplatinum), a platinum compound, has been an important chemotherapeutic drug for the treatment of many cancers, including ovarian, lung, testicular, and bladder cancers, as a single agent or … dhfl housing finance limitedWebThe Alternative Lengthening of Telomeres (ALT) pathway stimulates telomere elongation and prevents cellular senescence in approximately 60% of osteosarcoma. cigar shop buffalo