Cisplatin lysosomes

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August undefined, 2024

MiTF is Associated with Chemoresistance to Cisplatin in A549 …

WebCisplatin, a class of platinum-containing anticancer drugs for the treatment of solid tumors, is a substrate of OCT2 and MATE1/MATE2-K. OCT2 is expressed in the basolateral … WebJun 5, 2024 · Disrupting lysosomes with bafilomycin A1 increased the sensitivity of resistant cells to CDDP (Fig. 2K ). Fig. 2: Therapy-activated TFEB acts as a critical regulator to … burrow and soar yarn

Bafilomycin A1 increases the sensitivity of tongue squamous cell ...

WebNCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. WebThe nanomaterial consists of peptide amphiphiles, which self-assemble into nanoparticles, colocalize with the lysosome, and change conformation to nanofibrils due to lysosomal pH shift, which leads to the disruption of the lysosome, cell death, and cisplatin sensitization. WebJun 5, 2024 · Disrupting lysosomes with bafilomycin A1 increased the sensitivity of resistant cells to CDDP (Fig. 2K ). Fig. 2: Therapy-activated TFEB acts as a critical regulator to control lysosomal... hammurabi code builders law

Lysosomal inhibition sensitizes TMEM16A-expressing …

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WebJun 2, 2016 · Cisplatin is a widely prescribed anticancer drug, which triggers cell death by covalent binding to a broad range of biological molecules. Among cisplatin targets, … WebApr 15, 2003 · Cisplatin (CP) is a component of standard treatment regimens for testicular, ovarian, bladder, cervical, head and neck and small-cell and nonsmall-cell lung cancers (Ozols and Williams, 1989 ... hammurabi codes eye for an eye numberWebCytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. ... Y. et al. Cisplatin-induced autophagy protects breast cancer cells from apoptosis by regulating ... hammurabi and his code

"WebOct 28, 2024 · Annexin A2 (ANXA2) is a phospholipid-binding protein involving in organelle membrane integrity function, suggesting its important role in autophagy and lysosome homeostasis. It implicates ANXA2... " - Cisplatin lysosomes

Cisplatin lysosomes

Autophagy modulating agents as chemosensitizers for cisplatin …

WebSep 25, 2024 · We investigated whether triggering lysosomal membrane permeabilization (LMP) or suppressing autophagy can restore cisplatin … WebOct 1, 2024 · The Lysosomal pH shift induces nanofibril formation and lysosomal membrane permeation, thereby releasing the lysosomal contents into the cytoplasm and inducing LMP mediated cell death and cisplatin sensitization. Figure …

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WebMay 10, 2024 · This HIF/Ferritin axis is responsible for etoposide- and cisplatin-induced iron reduction in lysosomes and stemness of SCLC cells. This work demonstrates that … WebBafilomycin A1 increases the sensitivity of tongue squamous cell carcinoma cells to cisplatin by inhibiting the lysosomal uptake of platinum ions but not autophagy. Author links open overlay panel Hong-Ying Chu a b 1, Wei Wang a 1, Xue Chen a, ... Lysosome is a potential target for increasing the cytotoxicity of DDP.

WebAutophagy is defined as the process of intracellular degradation of cytoplasmic materials in the lysosome; however, the correlation between autophagy and drug resistance remains controversial. ... The cisplatin (DDP)-resistant human lung adenocarcinoma A549 cell line (A549/DDP) and its parental A549 cell line were purchased from Rui Cong ... WebConfocal microscopy studies for 2a-Cl suggest that complexes localize preferentially in the lysosomes and to a lesser extent on the cytoplasm, but ultimately causing damage to the mitochondria. Finally, the potential photodynamic behaviour of scarcely toxic complexes 2b-Cl, 2b-PF6, 2c-Cl and 3a-PF6 was also studied

WebMar 1, 2024 · Cisplatin (CDDP) is a widely used agent in the treatment of neuroblastoma. Unfortunately, the development of acquired chemoresistance limits its clinical use. To gain a detailed understanding of the mechanisms underlying the development of such chemoresistance, we comparatively analyzed established … WebJan 1, 2016 · Ctr1 imports platinum-based drugs into the cell. The drug enters the nucleus, induces DNA crosslinking, resulting in DNA damage, cell cycle arrest and apoptosis (a). …

WebDec 8, 2024 · Cisplatin, activated by intracellular hydrolysis of chlorides, binds to DNA to form monoadducts as well as intra- and interstrand DNA cross-links [ 3 ]. As a result, it …

WebSep 25, 2024 · We investigated whether triggering lysosomal membrane permeabilization (LMP) or suppressing autophagy can restore cisplatin susceptibility in lung cancer with acquired chemoresistance. Cisplatin IC 50 in A549Pt (parental) and A549cisR (cisplatin resistant) cells was 13 μM and 47 μM, respectively. hammurabi code and hebrew lawWebSep 21, 2015 · Platinum-based cisplatin is a first-line therapeutic agent used in the treatment of multiple cancers, including ovarian cancer. Cisplatin acts by inducing DNA damage, triggering cell cycle arrest, and initiating apoptosis ( 4 ). However, many ovarian cancer patients develop acquired cisplatin resistance, resulting in failure of … hammurabi code women\u0027s rightsWebAug 3, 2024 · The eukaryotic endomembrane system (EMS) is a set of interrelated membrane-bound organelles that include the endoplasmic reticulum (ER), Golgi, lysosome and the plasma membrane, as well as the vesicles trafficking between them. It is responsible for numerous cellular processes, such as endocytosis and exocytosis. burrow and chase lsu